Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Allogeneic transplantation of an adipose-derived stem cell (ASC) sheet combined with artificial skin accelerates wound healing in a rat wound model of type 2 diabetes and obesity Running title: Allogeneic ASC sheet therapy for diabetic ulcer

Allogeneic Transplantation of an Adipose-Derived Stem Cell Sheet Combined With Artificial Skin Accelerates Wound Healing in a Rat Wound Model of Type 2 Diabetes and Obesity.

One of the most common complications of diabetes is diabetic foot ulcer. Diabetic ulcers do not heal easily due to diabetic neuropathy and reduced blood flow, and nonhealing ulcers may progress to gangrene, which necessitates amputation of the patient's foot. This study attempted to develop a new cell-based therapy for nonhealing diabetic ulcers using a full-thickness skin defect in a rat model...

The Effect of Transplantation of Collagen Hydrogel with Adipose-Derived Mesenchymal Stem Cells on Burn Wound Healing in Rats

Background: Cell therapy is one of the most challenging methods in the healing of burn wounds in the world. The present study aimed to determine the effect of collagen hydrogel with adipose-derived mesenchymal stem cells on burn wound healing in an animal model. Materials and Methods: The present study was experimentally performed on 24 Wistar rats. Burn wounds were created on the skin of rats...

Skin wound healing following the spray of human abdominal adipose tissue-derived mesenchymal stem cells in diabetic male rat

Introduction: Diabetes is rising worldwide and impaired wound healing is one of its major complications. This study aimed to determine the effects of adipose-derived mesenchymal stem cells (MSCs) on wound healing in diabetic rats. Materials and Methods: In this experimental study, abdominal adipose tissue was obtained from 10 patients who underwent an abdominoplasty. MSCs were isolated from adi...

Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats.

AIMS Stem cells are a new hope to ameliorate impaired diabetic wound healing. The purpose of this study was to evaluate the effect of adipose tissue derived mesenchymal stem cells (AD-MSCs) on wound healing in a diabetic rat model. METHODS Twenty-six rats became diabetic by a single intraperitoneal injection of streptozotocin. Six rats served as non-diabetic (non-DM). Diabetic rats were divid...